Fetal growth depends on availability of nutrients derived from maternal circulation and transferred through the placenta. It is thus conceivable that changes in the placental function would impact fetal growth. Here, we report that placental growth and gene expression were affected in N-STZ pregnancies that have given birth to macrosomic newborns.Other than reported elsewhere, we observed loss of only one MMR protein, MSH6, and this in only one case. This finding is in line with a previous study in tumors from Greek patients that demonstrated no loss for the MMR proteins tested. In conclusion, this study shows that ixabepilone had a manageable safety profile with neutropenia, sensory neuropathy, arthralgias/myalgias and fatigue being the most prominent adverse events. Out of the 5 genetic, 5 mRNA and 12 protein markers examined in this study, none was associated with patient ORR and drug toxicity. However, despite the descriptive use of pvalues, which poses a limitation to the study conclusions, some interesting marker correlations and prognostic effects were observed that merit further investigation. These include: the association of three ABCB1 variant T-alleles with PgR and ERpositivity, as well as with a better outcome for the corresponding patients; the positive association of MAPT mRNA expression and tau protein expression with the ER-positive phenotype, and their corresponding favorable prognostic impact; the inverse Ginsenoside-Ro correlation of MAPT mRNA expression with TopoIIa protein expression, with TopoIIa positivity being an unfavorable prognostic factor in our study; a positive interaction of TUBB3 mRNA expression with cumulatively high dose ixabepilone for patient survival. These markers were of potential merit in the prognostic setting in this small cohort of patients.The infection by root pathogenic oomycetes is initiated by the release from sporangia of motile, biflagellate and wall-less zoospores, which encyst and adhere to the host surface following a chemotactically and electrotactically swimming stage. The cysts germinate by forming the germ tubes and start to penetrate the plant cuticle directly with the aid of secreted enzymes and colonize host tissues. Previous studies have shown that these pre-infection structures are rich in molecules involved in establishment of infection and elicitation of plant defenses. The unraveling of the molecular processes regulating the life cycle of Phytophthora is therefore important to identify determinants of pathogenesis and develop appropriate control strategies. The heterothallic oomycete Phytophthora capsici Leonian can cause seed, root, crown, foliar and fruit rot on a number of important crops, such as solanaceous crops, cucurbits and bean crops. P. capsici is also recorded as a pathogen of Allium cepa, Nicotiana benthamiana and Arabidopsis thaliana. To date, the diseases caused by P. capsici have become devastating ones of global economic importance. The cost that P. capsici inflicts upon worldwide vegetable production is estimated. Unfortunately, the control of P. capsici is a difficult task as there has been no available effective chemical or cultural strategy. In order to improve methods for controlling Phytophthora diseases, it is essential to understand the molecular mechanisms by which the pathogen suppresses or escapes the host plant defenses.