Whereas gastrointestinal organs are largely invested by the visceral peritoneum, some other organs, including the esophageal adventitia or duodenum peritoneum, are invested by parietal peritoneum. Furthermore, peritoneal tissue is histologically variable. For example, gastric peritoneum shows a fat-less thin histologic appearance, whereas colonic peritoneum shows at hick histologic appearance with abundant fat tissue. Such anatomical and histological heterogeneity of peritoneum tissue may contribute to the transcriptional diversity of SPFs. Next, interestingly, SPFs with non-GIF like phenotype showed transcriptional similarity with vascular adventitial fibroblasts. Anatomically, vascular adventitia and serosa have continuity in the lung, and vascular adventitia and Stattic serosal tissue are known to contain a prominent elastic fiber component. Previously, we reported both VAFs and SPFs possess robust tumor progression ability, and our results Ibandronate sodium suggest the existence of a fibroblastic subgroup with special pathological function. Therefore, our data can potentially provide not only basic data about physiological function, but also important clues to estimate pathological processes of fibroblasts. In conclusion, GIFs are a distinct subgroup within the whole body, and were subclassified depending on their anatomical site or organ. These heterogeneous transcriptional phenotypes were mainly discriminated by the expression pattern of the genes related to transcriptional regulation, humoral signaling ligands, and extracellular matrix remodeling. The site-specific phenotypes of fibroblasts are related to embryogenesis, and may contribute to create the organ- or site-specific microenvironment necessary to maintain tissue homeostasis. These new data further demonstrate the wide spectrum of physiological and pathological roles these cells can play, and can be an important resource for future organogenetic studies. The pathogenesis of NAFLD is largely at tribute to insulin resistance induced dyslipidemia and hypercholesterolemia, which are also common features of atherosclerosis.