The decay of the amount of each peptide is a two steps mechanism, characterized by a double exponential evolution of their amounts: the first one is at least partially attributed to oxidation of specific amino acids, while the second one corresponds to further degradation of the protein. By confronting these results to the structural parameters computed from MD simulations, we were able to conclude that protein parts with increased RMSD are more susceptible to modifications. In addition, involvement of amino acid side-chains in a large number of hydrogen bonds may have a protective effect against modifications. Finally, at the level of individual amino acid side chains we were able to observe that their increased exposure to solvent renders them highly susceptible to oxidative and other modifications like side chain fragmentation. Generally, none of the structural parameters alone is able to account for the behavior of peptides during radiation, NVP-BKM120 however, when combined they provide a valuable insight into the relationship of protein structure and susceptibility to oxidation. Major depressive disorder, also called major depression, is a debilitating and recurring SB431542 ALK inhibitor psychiatric disorder, with a worldwide prevalence of approximately17%. An epidemiological survey carried out from 2001 to 2005, of 113 million adults from four provinces in China demonstrated a 6% prevalence rate for depression. Yet, despite this high prevalence, the pathogenesis of this disorder is not yet fully understood. It has been suggested that stress and altered monoamine, hypothalamic-pituitaryadrenal axis, brain-derived neurotrophic factor, and glutamatergic neurotransmission might be implicated in the pathogenesis of major depression. A large body of epidemiological evidence shows that life event stressors are major vulnerability factors for depression. Furthermore, a relationship between marital status, psychological distress and major depression has been suggested.Longitudinal, community-based data from program demonstrated that marital disruption was associated with higher prevalence rates of major depression in men, suggesting that this type of life event stressor conferred a high risk of disease for men.