Finally, our study revealed extensive structural alterations in the SCZ patients as compared to the CTRLs. Our findings are consistent with previous studies, which implicate frontal, temporal and parietal regions, as those most Temozolomide frequently showing GMV reductions in the SZC patients. These findings are also consistent with the suggested conception that schizophrenia might arise from dysfunction of fronto-temporal circuits. Taken together, our findings suggest that GMV in these brain regions may account for alterations related to interaction that underpins the comorbidity of both conditions and the associated symptoms. Our results are in consonance with those found by Bruhl et al. and might point to a distinct clinical and neuroanatomical basis in schizophrenic patients with comorbid anxiety. However, the hypothesis that compensatory GMV increases in the dlPFC in association with anxiety��s abnormal emotion suppression might be related to smaller GMV decreases in the dlPFC in schizophrenic patients with comorbid anxiety requires further investigation. We also observed important correlations between GMV and the clinical data. Our findings indicated a negative correlation between the SCZ/ANX group and the social anxiety scale in the bilateral superior temporal gyri. The superior temporal gyrus has shown to be an important structure in social cognition processes and temporal lobe alterations have also been found in PD. Therefore, deficits in this brain region might be related to difficulties to Y-27632 dihydrochloride adequately process relevant social stimuli, such as the perception of emotions in facial stimuli, since this structure has been observed to play an important role in the perception of emotions in facial stimuli. Interestingly, previous clinical studies have related clinically meaningful anxiety with schizophrenia, and, specifically, with poorer psychosocial function. Additionally, we also observed a negative correlation the PANSS Negative Symptoms Subscale and left Heschl`s gyrus, right superior temporal gyrus, left superior frontal gyrus, left inferior occipital gyrus and right inferior temporal gyrus. In line with prior literature, these findings suggest that structural abnormalities in temporal cortices may contribute to the pathophysiology of schizophrenia since progressive volume reduction has been reported in the temporal lobe as well as Heschl’s gyrus/planum temporale gray matter. It is worthwhile to point out that abnormalities in the temporal lobe have also been related to negative symptomatology. Furthermore, structural studies in social anxiety disorder have also observed anatomical differences in temporal brain regions suggesting that temporal brain areas might be affected by the comorbidity effects of both disorders.