One of the matrix metalloproteinases inhibitor family involved in the epithelial to the Leonurine-hydrochloride mesenchymal transition, TIMP1, emerged in our profile as a protective factor. The presence of EPOR as a risk Epimedin-A factor is another pathway to be explored in further studies. A recent study has described a paracrine mechanism of growth related to EPOR/EPO interaction, apparently independent of exogenous EPO. These interesting observations about the role of these genes in ovarian cancer remain to be undoubtedly established and cannot be conclusively derived from this descriptive study. An important advantage of our profile is that it has been developed from formalin-fixed, paraffin embedded tissue thus allowing its use in a widespread clinical setting without the need of frozen tumor tissue, which is usually only available in tertiary referral hospitals or research centers that have frozen tissue banks. Although our series is quite homogeneous, the fact that our study analyzed a relatively small number of samples may seem a limitation. Notwithstanding the majority of the profiling studies previously published on ovarian cancer used a similar number of cases. Our profile could be used as prognostic tool to enable clinicians to identify those high risk patients who will potentially benefit from alternative drug combinations. Moreover, due to the successful introduction of the antiangiogenic drugs in resistant advanced epithelial ovarian cancer, we could consider patients with a high risk to benefit from a combination of platinum-taxane chemotherapy with a novel antiangiogenic drug. Nevertheless, although our data suggest the potential utility of this approach, the prognostic value of our qRT-PCR based angiogenesis-related gene expression profile should be further evaluated in prospective studies of patients with advanced epithelial ovarian cancer. Thus, we investigated the effect of the other two key parameters on the evolution of transmitted resistance in Botswana. The rate of acquired resistance depends upon adherence, viral replication rate, and the specific mutations that arise.