Children usually initiate ART at tertiary hospitals and can be referred back to a district hospital when their health becomes stable. Transition to adult clinic should normally occur at age 15. The Thai paediatric ART programme is an innovative and holistic model not previously evaluated. We set out to investigate the experiences of services in the care continuum, from transmission of HIV through to transition to adult services. We sought the multiple perspectives of service-users,ADDA 5 hydrochloride service-providers and ‘policy actors’ to better understand what works well and why and to learn lessons that can inform programme evolution. Paediatric ART clinic service-users participated in qualitative interviews using a semistructured guide designed to elicit detail. Information was asked about family and socio-economic situations, HIV support structures, stigma, HIV education, perceptions about services, challenges related to HIV and changes over time. The interviews were carried out in Thai or local Northeastern dialect by a female PLHIV researcher. Participants were selected purposively by the HIV care teams on clinic days to represent a range of different experiences including: adolescence; orphanhood; a range of income levels; adherence issues; experienced social exclusion,Drotaverine hydrochloride stigma or abuse; psychosocial difficulties or isolation; HIV disclosure issues. Registered patients who had not experienced any of these HIV related difficulties were rare; effort was made to ensure positive and negative experiences were elicited. Interviews also took place with prior caregivers of orphans living at orphanages. Using convenience sampling participants were invited for telephone interview if contact information was still available to discuss perceptions about HIV and service availability. Interviews were undertaken in Thai by a member of orphanage staff with whom caregivers were acquainted. The relationships between paediatric HIV services, serviceusers’ experiences of HIV and their care-seeking behaviour are complex and not well understood in Asia. Using a qualitative methodology we have described the stages of the journey through paediatric HIV infection from different perspectives.