The CC genotype and C allele frequencies of this SNP were significantly increased in patients compared to controls while the frequencies of the CT genotype and T allele were significantly decreased, indicating that the CC genotype and C allele were predisposing factors for pediatric uveitis. Based on this association, we further designed a study to investigate whether this SNP affected the expression of Ets-1. Our study demonstrated that the Ets-1 expression was significantly upregulated in healthy individuals carrying the CC genotype of rs10893872. We performed this assay in healthy individuals since immunosuppressive treatment in the patient group could possibly alter gene expression. SNP rs10893872 of Ets-1 was found to be highly associated with SLE. Differently, there was no significant association of SNP rs10893872 of Ets-1 found in ocular Behc?et��s disease, Vogt�C Koyanagi�CHarada syndrome, and Fuchs Benzoylpaeoniflorin uveitis syndrome in Chinese Han patients with previous works. The transcription factor Ets-1, originally discovered as an oncogene within the genome of the avian leukemia virus, shows a dual nature in autoimmune diseases. It was reported to be overexpressed in rheumatoid arthritis synovial membrane and to be involved in the destructive pathway of RA. Nevertheless, the expression of Ets-1 in SLE was lower in PBMCs as compared with that of healthy subjects. Ets-1 also plays important roles in regulating the differentiation of T helper cell subsets, cytotoxic T cells, B cells and other cell types, and controlling the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. The regulatory T cell lineage is a key player maintaining peripheral selftolerance and modulating almost any type of immune responses. Julia K. Polansky et. al. have proposed that Ets-1 binds to the CpGrich Treg specific demethylated region only in its demethylated state, thereby restricting stable Foxp3 expression to the Treg lineage. Concerning the important roles of Ets-1, the increased frequency of the rs10893872 CC genotype in patients and the increased expression of Ets-1 in CC genotype carriers suggest that Ets-1 is a predisposing factor in pediatric uveitis. It is worthwhile to mention that there are several limitations in the present study. The sample of patients in our study is relatively small and only Han Chinese cohorts are included. Therefore, the results observed in this study need to be confirmed using a large sample size and should include other ethnic populations. We have not investigated whether the SNP rs10893872 influencing Ets-1 expression can also affect the production of cytokines importantly involved in pediatric uveitis development. Further studies are needed to clarify this issue. In conclusion, our study has identified the associations of rs2910164 and rs10893872 with pediatric uveitis. Furthermore, our study has suggested that SNP rs10893872 may affect the genetic predisposition to this 14alpha-hydroxy-Sprengerinin-C disease possibly through modulating the expression of Ets-1. Brain-derived neurotrophic factor is considered a valid indicator of depressive state. Clinical studies have indicated that serum or plasma BDNF levels are decreased in patients with untreated major depressive disorder.